Santa Cruz is a Portuguese municipality on the island of Madeira, Autonomous Region of Madeira, headquartered in the city and homonymous parish.

It has 81.50 km² and 43 005 inhabitants, subdivided into 5 parishes.

The metropolitan area of Funchal, which includes the municipalities of Câmara de Lobos, Ribeira Brava, Santa Cruz and Machico, has a population of over 225,000.

In this municipality, the Madeira Cristiano Ronaldo International Airport is located here.